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Clinical Characteristics of Patients with Unexplainable Hypothalamic Disorder Diagnosed by the Corticotropin-releasing Hormone Challenge Test: a Retrospective Study by Yuji Hataya; Marie Okubo; Takuro Hakata; Kanta Fujimoto; Toshio Iwakura; Naoki Matsuoka is a Medicine article available to read on EtoBox.

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## Abstract ## Background The corticotropin-releasing hormone (CRH) challenge test can distinguish the disorders of the hypothalamus from those of the pituitary. However, the pathophysiology of hypothalamic disorder (HD) has not been fully understood. This study aimed to elucidate the clinical characteristics of patients with unexplainable HD, diagnosed by the CRH challenge test. ## Methods We retrospectively reviewed patients who underwent the CRH challenge test. Patients were categorized into four groups as follows: patients with peak serum cortisol ≥18 μg/dL were assigned to the normal response (NR) group (n = 18), among patients with peak serum cortisol < 18 μg/dL and peak adrenocorticotropic hormone (ACTH) increase ≥two-fold, patients without obvious background pathology were assigned to the unexplainable-HD group (n = 18), whereas patients with obvious background pathology were assigned to the explainable-HD group (n = 38), and patients with peak serum cortisol < 18 μg/dL and peak ACTH increase n = 15). Inter-group comparisons were performed based on clinical characteristics. ## Results In the CRH challenge test, the peak plasma ACTH levels were significantly lower in the une

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Author

Yuji Hataya; Marie Okubo; Takuro Hakata; Kanta Fujimoto; Toshio Iwakura; Naoki Matsuoka

Publisher

Springer Science and Business Media LLC

Published

2022

Language

EN

Field

Medicine (Health Sciences)