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## Recognition of dengue NS1 antigen and compulsory case reporting Recently, dengue virus NS1 antigen detection in travellers on arrival at airports in Taiwan was instrumental in detection of 19 RT-PCR-negative travellers who would otherwise have been labelled dengue-negatives: two turned IgM positive on Days 17 or 18 of illness. 1 Furthermore, in Malaysia 42 of 55 patients with a clinical diagnosis of acute dengue were positive only for NS1 but were negative for both RT-PCR and virus isolation. 2 None could have been notified to government organisations. Notifications to government agencies are based on clinical and laboratory categorisation of a probable or confirmed case. As a rule rather than the exception, WHO guidelines 3 are applicable in dengue-endemic areas, including India. The WHO case definition of a probable or confirmed dengue case includes positive serology, virology or molecular biology evidence of infection. 1 Nevertheless, the contribution of NS1 antigen detection, now readily available in a point-of-care assay format, towards dengue diagnosis justifies urgent revision of the WHO criterion for a probable or confirmed dengue case. 3 These recommendations were draft

Who reads Recognition of dengue NS1 antigen and compulsory case reporting?

Author

Subhash C. Arya; Nirmala Agarwal

Publisher

Elsevier Science; Oxford University Press; Oxford University Press (OUP); ScienceOpen (ISSN 0035-9203)

Published

2009

Language

EN

Field

Medicine (Health Sciences)