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Circulating Inflammatory Biomarkers in Relation to Brain Structural Measurements in a Non-demented Elderly Population by Yian Gu; Robert Vorburger; Nikolaos Scarmeas; José A. Luchsinger; Jennifer J. Manly; Nicole Schupf; Richard Mayeux; Adam M. Brickman is a Neuroscience article available to read on EtoBox.
What is Circulating Inflammatory Biomarkers in Relation to Brain Structural Measurements in a Non-demented Elderly Population about?
The aim of this investigation was to determine whether circulating inflammatory biomarkers c-reactive protein (CRP), interleukin-6 (IL6), and alpha 1-antichymotrypsin (ACT) were related to structural brain measures assessed by magnetic resonance imaging (MRI). High-resolution structural MRI was collected on 680 non-demented elderly (mean age 80.1years) participants of a community-based, multiethnic cohort. Approximately three quarters of these participants also had peripheral inflammatory biomarkers (CRP, IL6, and ACT) measured using ELISA. Structural measures including brain volumes and cortical thickness (with both global and regional measures) were derived from MRI scans, and repeated MRI measures were obtained after 4.5years. Mean fractional anisotropy was used as the indicator of white matter integrity assessed with diffusion tensor imaging. We examined the association of inflammatory biomarkers with brain volume, cortical thickness, and white matter integrity using regression models adjusted for age, gender, ethnicity, education, APOE genotype, and intracranial volume. A doubling in CRP (b=-2.48, p=0.002) was associated with a smaller total gray matter volume, equivalent to a
Who reads Circulating Inflammatory Biomarkers in Relation to Brain Structural Measurements in a Non-demented Elderly Population?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Yian Gu; Robert Vorburger; Nikolaos Scarmeas; José A. Luchsinger; Jennifer J. Manly; Nicole Schupf; Richard Mayeux; Adam M. Brickman
- Publisher
- Elsevier BV
- Published
- 2017
- Language
- EN
- Field
- Neuroscience (Life Sciences)