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A Single-centre Protocol Using Low-dose Urokinase for Catheter-directed Thrombolysis in the Treatment of Acute Lower Limb Ischaemia by Tao Shi; Yongbao Zhang; Chenyang Shen; Jie Fang is a Medicine article available to read on EtoBox.

What is A Single-centre Protocol Using Low-dose Urokinase for Catheter-directed Thrombolysis in the Treatment of Acute Lower Limb Ischaemia about?

Objectives Catheter-directed thrombolysis is one of the main treatments for acute limb ischaemia. Urokinase is still a widely used thrombolytic drug in some regions. However, there needs to be a clear consensus on the protocol of continuous catheter-directed thrombolysis using urokinase for acute lower limb ischaemia. Methods A single-centre protocol of continuous catheter-directed thrombolysis with low-dose urokinase (20,000 IU/hour) lasting 48–72 h for acute lower limb ischaemia was proposed based on our previous experiences. A retrospective study from June 2016 to December 2020 was conducted to evaluate the efficacy and safety of this protocol. The target lesion revascularisation, amputation and death were also monitored during follow-up. The Kaplan–Meier estimator was used for the subgroup analysis, and univariate and multivariate Cox regression analysis was applied to identify risk factors for reinterventions and death. Results 90 lower limbs were involved, including 51 Rutherford Grade I, 35 Grade IIa and four Grade IIb. During a 60.8-h thrombolysis, 86 cases (95.5%) were considered effective according to the angiogram. No major bleeding complication occurred during thromboly

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Author

Tao Shi; Yongbao Zhang; Chenyang Shen; Jie Fang

Publisher

SAGE Publications

Published

2023

Language

EN

Field

Medicine (Health Sciences)