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Can I read Plasma Biomarkers and Positron Emission Tomography Tau Pathology in Progressive Supranuclear Palsy on EtoBox?
Plasma Biomarkers and Positron Emission Tomography Tau Pathology in Progressive Supranuclear Palsy by Shu‐Yi Huang; Shu‐Fen Chen; Mei Cui; Meng Zhao; Xue‐Ning Shen; Yu Guo; Ya‐Ru Zhang; Wei Zhang; Hui‐Fu Wang; Yu‐Yuan Huang; Wei Cheng; Chuan‐Tao Zuo; Qiang Dong; Jin‐Tai Yu is a Medicine article available to read on EtoBox.
What is Plasma Biomarkers and Positron Emission Tomography Tau Pathology in Progressive Supranuclear Palsy about?
Background: Development of disease-modifying therapeutic trials of progressive supranuclear palsy (PSP) urges the need for sensitive fluid biomarkers. Objectives: The objectives of this study were to explore the utility of plasma biomarkers in the diagnosis, differential diagnosis, and assessment of disease severity, brain atrophy, and tau deposition in PSP. Methods: Plasma biomarkers were measured using a single-molecule array in a cohort composed of patients with PSP, Parkinson's disease (PD), multiple system atrophy with predominant parkinsonism (MSA-P), and healthy controls (HCs). Results: Plasma neurofilament light chain (NfL) outperformed other plasma makers (ie, glial fibrillary acidic protein [GFAP], phosphorylated-tau 181 [p-tau181], amyloid-β 1-40, amyloid-β 1-42) in identifying PSP from HC (area under the curve [AUC] = 0.904) and from MSA-P (AUC = 0.711). Plasma GFAP aided in distinguishing PSP from HC (AUC = 0.774) and from MSA-P (AUC = 0.832). It correlated with brainstem atrophy and higher regional tau accumulation. However, plasma p-tau181 neither helped in diagnosis nor was it associated with clinical or neuroimaging measures. Conclusions: Plasma NfL and GFAP showed
Who reads Plasma Biomarkers and Positron Emission Tomography Tau Pathology in Progressive Supranuclear Palsy?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Shu‐Yi Huang; Shu‐Fen Chen; Mei Cui; Meng Zhao; Xue‐Ning Shen; Yu Guo; Ya‐Ru Zhang; Wei Zhang; Hui‐Fu Wang; Yu‐Yuan Huang; Wei Cheng; Chuan‐Tao Zuo; Qiang Dong; Jin‐Tai Yu
- Publisher
- Wiley
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)