Can I read Multidrug resistance protein expression of adult T-cell leukemia/lymphoma on EtoBox?
Multidrug resistance protein expression of adult T-cell leukemia/lymphoma by Takeshi Yasunami; Yan-hua Wang; Kazue Tsuji; Minoko Takanashi; Yasuaki Yamada; Toshiko Motoji is a Medicine article available to read on EtoBox.
What is Multidrug resistance protein expression of adult T-cell leukemia/lymphoma about?
In adult T-cell leukemia/lymphoma (ATL), it is difficult to achieve remission and the reason for the resistance to chemotherapeutic agents may be linked to the presence of multidrug resistance (MDR) proteins. Lung resistance-related protein (LRP), multidrug resistance-associated protein and P-glycoprotein are three MDR proteins which we examined in ATL cells using multiparametric flow cytometry and real-time RT-PCR. LRP was highly expressed and suppressing LRP function increased doxorubicin accumulation in nuclei. This indicates LRP may be contributing to drug resistance in ATL patients, and the suppression of LRP function could be a new strategy for ATL treatment.
Who reads Multidrug resistance protein expression of adult T-cell leukemia/lymphoma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Takeshi Yasunami; Yan-hua Wang; Kazue Tsuji; Minoko Takanashi; Yasuaki Yamada; Toshiko Motoji
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0145-2126)
- Published
- 2007
- Language
- EN
- Field
- Medicine (Health Sciences)