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Can I read Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif on EtoBox?
Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif by Nina Klee; Pui Ee Wong; Beatriz Baragaña; Farah El Mazouni; Margaret A. Phillips; Michael P. Barrett; Ian H. Gilbert is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif about?
Trypanosoma brucei, the parasite that causes human African trypanosomiasis, is auxotrophic for purines and has specialist nucleoside transporters to import these metabolites. In particular, the P2 aminopurine transporter can also selectively accumulate melamine derivatives. In this Letter, we report the coupling of the melamine moiety to 2-hydroxy APA, a potent ornithine decarboxylase inhibitor, with the aim of selectively delivering this compound to the parasite. The best compound described here shows an increased in vitro trypanocidal activity compared with the parent.
Who reads Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Nina Klee; Pui Ee Wong; Beatriz Baragaña; Farah El Mazouni; Margaret A. Phillips; Michael P. Barrett; Ian H. Gilbert
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0960-894X)
- Published
- 2010
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)