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TP53 alterations and patterns of carcinogen exposure in a U.S. population-based study of bladder cancer by Karl T. Kelsey; Tomoko Hirao; Shuya Hirao; Tara Devi-Ashok; Heather H. Nelson; Angeline Andrew; Joanne Colt; Dalsu Baris; J. Steven Morris; Alan Schned; Margaret Karagas is a Medicine article available to read on EtoBox.

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## Abstract The molecular pathology of bladder cancer has been the subject of considerable interest, and current efforts are targeted toward elucidating the interrelationships between individual somatic gene loss and both etiologic and prognostic factors. Mutation of the __TP53__ gene has been associated with more invasive bladder cancer, and evidence suggests that __TP53__ mutation, independent of stage, may be predictive of outcome in this disease. However, there is no consensus in the literature that bladder carcinogen exposure is associated with inactivation of the __TP53__ gene. Work to date has been primarily hospital based and, as such, subject to possible bias associated with selection of more advanced cases for study. We examined exposure relationships with both __TP53__ gene mutation and TP53 protein alterations in a population‐based study of 330 bladder cancer cases in New Hampshire. Tobacco smoking was not associated with TP53 alterations. We found a higher prevalence of __TP53__ inactivation (__i.e.,__ mutation and nuclear accumulation) among hair dye users (odd ratio [OR] = 4.1; 95% confidence interval [CI] 1.2–14.7), and the majority of these mutations were transvers

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Author

Karl T. Kelsey; Tomoko Hirao; Shuya Hirao; Tara Devi-Ashok; Heather H. Nelson; Angeline Andrew; Joanne Colt; Dalsu Baris; J. Steven Morris; Alan Schned; Margaret Karagas

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square; Test accounts (ISSN 0020-7136)

Published

2005

Language

EN

Field

Medicine (Health Sciences)