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Functional polymorphisms and haplotypes in the promoter of the MMP2 gene are associated with risk of nasopharyngeal carcinoma by Gangqiao Zhou; Yun Zhai; Ying Cui; Wei Qiu; Hao Yang; Xiumei Zhang; Xiaojia Dong; Ying He; Kaitai Yao; Hongxing Zhang; Yong Peng; Xiaoyan Yuan; Lianteng Zhi; Xiaoai Zhang; Fuchu He is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Functional polymorphisms and haplotypes in the promoter of the MMP2 gene are associated with risk of nasopharyngeal carcinoma about?
## Communicated by Stephen Chanock Matrix metalloproteinases (MMPs) play important roles in cancer initiation and development. Several polymorphisms in the promoters of a number of MMP genes, which can affect the respective MMP production in an allele-specific manner, have been well characterized. We examined whether these functional polymorphisms were related to the risk of nasopharyngeal carcinoma (NPC) in Chinese populations. Eight polymorphisms in the promoter of MMP1, MMP2, MMP3, MMP7, MMP9, MMP12, and MMP13 were genotyped in two independent case-control populations; one is from Guangxi province (593 patients with NPC and 480 controls), and the other is from Guangdong province (239 patients and 286 controls). We observed significantly increased susceptibility to NPC for the MMP2 -1306CC (rs243865:C4T) (odds ratio [OR] 5 2.01, 95% confidence interval [CI] 5 1.30-3.10) and -735CC (rs2285053:C4T) (OR 5 1.56, 95% CI 5 1.17-2.09) genotype carriers compared with noncarriers in the Guangxi population. This association was confirmed in the Guangdong population (for -1306CC: OR 5 2.19, 95% CI 5 1.21-3.96; for À735CC: OR 5 1.60, 95% CI 5 1.13-2.28). The C -1306 -C -735 haplotype was als
Who reads Functional polymorphisms and haplotypes in the promoter of the MMP2 gene are associated with risk of nasopharyngeal carcinoma?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Gangqiao Zhou; Yun Zhai; Ying Cui; Wei Qiu; Hao Yang; Xiumei Zhang; Xiaojia Dong; Ying He; Kaitai Yao; Hongxing Zhang; Yong Peng; Xiaoyan Yuan; Lianteng Zhi; Xiaoai Zhang; Fuchu He
- Publisher
- Hindawi Limited
- Published
- 2007
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)