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Cognitive‐nigrostriatal relationships in de novo, drug‐naïve Parkinson's disease patients: A [I‐123]FP‐CIT SPECT study by Flavio Nobili; Claudio Campus; Dario Arnaldi; Fabrizio De Carli; Gaia Cabassi; Andrea Brugnolo; Barbara Dessi; Silvia Morbelli; Gianmario Sambuceti; Giovanni Abbruzzese; Guido Rodriguez is a Medicine article available to read on EtoBox.

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## Abstract To unveil cognitive‐nigrostriatal correlations in Parkinson's disease (PD), 30 de novo, drug‐naïve PD patients and 15 patients with essential tremor (Controls, CTR) underwent a neuropsychological (NPS) battery and brain SPECT with [I‐123]Ioflupane, as a biomarker of nigrostriatal function. Automatic extraction of uptake at caudate and putamen level was conducted through the BasGan software, also allowing partial volume effect correction. Because of the multicollinearity among neuropsychological tests and among SPECT variables, factor analysis was applied to 16 neuropsychological scores; moreover, the four SPECT variables were merged into a mean SPECT value (mSPECT). Factor analysis identified four NPS factors: a dys‐executive (NPS‐EX), a visuospatial (NPS‐VS), a verbal memory (NPS‐VM), and a “mixed” (NPD‐MIX) factor. In PD group, there were inverse correlations between UPDRS‐III score and both NPS‐VS (__P__ < 0.01) and mSPECT (__P__ < 0.05), and a direct correlation between mSPECT and NPS‐EX (__P__ < 0.05). Post hoc analysis showed a direct correlation between NPS‐EX and caudate uptake in both hemispheres (__P__ < 0.05). Moreover, inverse correlations were found between

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Author

Flavio Nobili; Claudio Campus; Dario Arnaldi; Fabrizio De Carli; Gaia Cabassi; Andrea Brugnolo; Barbara Dessi; Silvia Morbelli; Gianmario Sambuceti; Giovanni Abbruzzese; Guido Rodriguez

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-3185)

Published

2010

Language

EN

Field

Medicine (Health Sciences)