Opening book details…
Can I read Six-year results of the Eastern Cooperative Oncology Group trial of observation versus CMFP versus CMFPT in postmenopausal patients with node-positive breast cancer. on EtoBox?
Six-year results of the Eastern Cooperative Oncology Group trial of observation versus CMFP versus CMFPT in postmenopausal patients with node-positive breast cancer. by S G Taylor; M W Knuiman; L A Sleeper; J E Olson; D C Tormey; K W Gilchrist; G Falkson; S N Rosenthal; P P Carbone; F J Cummings is a Medicine article available to read on EtoBox.
What is Six-year results of the Eastern Cooperative Oncology Group trial of observation versus CMFP versus CMFPT in postmenopausal patients with node-positive breast cancer. about?
The Eastern Cooperative Oncology Group (ECOG) trial of adjuvant cyclophosphamide, methotrexate, fluorouracil, and prednisone (CMFP) or CMFP plus tamoxifen (CMFPT) for 1 year compared with observation alone in 265 postmenopausal patients with node-positive breast cancer is reported with 74 months median follow-up. Overall relapse-free survival tended to favor CMFPT (P = .08), but no survival differences existed between any treatment group. The addition of tamoxifen to CMFP led to slightly (but not significantly) better relapse-free status in all subgroups analyzed. Subgroup analysis based on stratification variables showed significant benefit from CMFP (+/- T) only in estrogen receptor (ER)-negative patients with respect to disease-free status (P = .0003), but not survival (P = .54). Relapse-free status was actually worse for CMFP-treated patients with ER-positive tumors, but not significantly so (P = .15). By multivariate analysis other significant risk factors for relapse-free status were primary tumor size, number of nodes pathologically involved, and the number of nodes examined. ER status was prognostic only for the observation group with the benefit from chemotherapy on ER-neg
Who reads Six-year results of the Eastern Cooperative Oncology Group trial of observation versus CMFP versus CMFPT in postmenopausal patients with node-positive breast cancer.?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- S G Taylor; M W Knuiman; L A Sleeper; J E Olson; D C Tormey; K W Gilchrist; G Falkson; S N Rosenthal; P P Carbone; F J Cummings
- Publisher
- American Society of Clinical Oncology; American Society of Clinical Oncology (ASCO) (ISSN 0732-183X)
- Published
- 1989
- Language
- EN
- Field
- Medicine (Health Sciences)