Can I read Computer-assisted design, synthesis and biological evaluation of novel pyrrolyl heteroaryl sulfones targeted at HIV-1 reverse transcriptase as non-nucleoside inhibitors on EtoBox?

Computer-assisted design, synthesis and biological evaluation of novel pyrrolyl heteroaryl sulfones targeted at HIV-1 reverse transcriptase as non-nucleoside inhibitors by Romano Silvestri; Marino Artico; Gabriella De Martino; Ettore Novellino; Giovanni Greco; Antonio Lavecchia; Silvio Massa; Anna Giulia Loi; Silvia Doratiotto; Paolo La Colla is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Computer-assisted design, synthesis and biological evaluation of novel pyrrolyl heteroaryl sulfones targeted at HIV-1 reverse transcriptase as non-nucleoside inhibitors about?

AbstractÐThree pyrrolyl heteroaryl sulfones (ethyl 1-[(1H-benzimidazol-2(3H)one-5-yl)sulfonyl]-1H-pyrrole-2-carboxylate, ethyl 1-[(1H-benzimidazol-5(6)-yl)sulfonyl]-1H-pyrrole-2-carboxylate and ethyl 1-[(1H-benzotriazol-5(6)-yl)sulfonyl]-1H-pyrrole-2-carboxylate) were designed as novel HIV-1 reverse transcriptase non-nucleoside inhibitors using structure-based computational methods. Although these compounds were inactive in the cell-based assay, they inhibited the target enzyme with micromolar potency (IC 50 s=2 mM, 3 mM and 9 mM, respectively).

Who reads Computer-assisted design, synthesis and biological evaluation of novel pyrrolyl heteroaryl sulfones targeted at HIV-1 reverse transcriptase as non-nucleoside inhibitors?

Author

Romano Silvestri; Marino Artico; Gabriella De Martino; Ettore Novellino; Giovanni Greco; Antonio Lavecchia; Silvio Massa; Anna Giulia Loi; Silvia Doratiotto; Paolo La Colla

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0968-0896)

Published

2000

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)