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Hypotension after Anesthesia Induction: Target-Controlled Infusion Versus Manual Anesthesia Induction of Propofol by Yildirim, Serap Aktas (author);Dogan, Lerzan (author);Sarikaya, Zeynep Tugce (author);Ulugol, Halim (author);Gucyetmez, Bulent (author);Toraman, Fevzi (author) is a Medicine article available to read on EtoBox.

What is Hypotension after Anesthesia Induction: Target-Controlled Infusion Versus Manual Anesthesia Induction of Propofol about?

Background: Post-induction hypotension frequently occurs and can lead to adverse outcomes. As target-controlled infusion (TCI) obviates the need to calculate the infusion rate manually and helps safer dosing with prompt titration of the drug using complex pharmacokinetic models, the use of TCI may provide a better hemodynamic profile during anesthesia induction. This study aimed to compare TCI versus manual induction and to determine the hemodynamic risk factors for post-induction hypotension. Methods: A total of 200 ASA grade 1–3 patients, aged 24 to 82 years, were recruited and randomly assigned to the TCI (n = 100) or manual induction groups (n = 100). Hemodynamic parameters were monitored with the pressure-recording analytic method. The propofol dosage was adjusted to keep the Bispectral Index between 40 and 60. Results: Post-induction hypotension was significantly higher in the manual induction group than in the TCI group (34% vs. 13%; __p__ < 0.001, respectively). The propofol induction dose did not differ between the groups (TCI: 155 (135–180) mg; manual: 150 (120–200) mg; __p__ = 0.719), but the induction time was significantly longer in the TCI group (47 (35–60) s vs. 150

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Author
Yildirim, Serap Aktas (author);Dogan, Lerzan (author);Sarikaya, Zeynep Tugce (author);Ulugol, Halim (author);Gucyetmez, Bulent (author);Toraman, Fevzi (author)
Publisher
MDPI AG
Published
2023
Language
EN
Field
Medicine (Health Sciences)

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