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Circulating betatrophin/ANGPTL8 levels correlate with body fat distribution in individuals with normal glucose tolerance but not those with glucose disorders by Zheng, Jing; Liu, Juan; Hong, Beverly S.; Ke, Weijian; Huang, Minmin; Li, Yanbing is a scholarly article available to read on EtoBox.

What is Circulating betatrophin/ANGPTL8 levels correlate with body fat distribution in individuals with normal glucose tolerance but not those with glucose disorders about?

## Background The relationship between betatrophin/ANGPTL8 and obesity has been investigated using body mass index (BMI); however, since BMI reflects overall adiposity rather than body fat distribution, it remains unclear whether fat deposition in different areas of the body affects betatrophin expression. Here, we investigated the correlation between circulating betatrophin levels and body fat distribution in patients with different glucose tolerance. ## Methods We performed a cross-sectional study in 128 participants with impaired glucose tolerance (IGT; __n__ = 64) or normal glucose tolerance (NGT; __n__ = 64). Circulating betatrophin levels were detected by enzyme-linked immunosorbent assay (ELISA). Body fat distribution (subcutaneous, visceral, and limb fat) was measured by magnetic resonance imaging (MRI) and a body fat meter. ## Results After controlling for age, sex, and BMI, betatrophin was correlated positively with visceral adipose tissue-to-subcutaneous adipose tissue ratio (VAT/SAT ratio; __r__ = 0.339, __p__ = 0.009) and negatively with body fat ratio (BFR; __r__ = − 0.275, __p__ = 0.035), left lower limb fat ratio (LLR; __r__ = − 0.330, __p__ = 0.011), and right lowe

Author

Zheng, Jing; Liu, Juan; Hong, Beverly S.; Ke, Weijian; Huang, Minmin; Li, Yanbing

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1472-6823)

Published

2020

Language

EN