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Neuronal Survival Using a Resorbable Synthetic Conduit as an Alternative to Primary Nerve Repair by C. Ljungberg; G. Johansson-Ruden; K. Junemo Bostrm; L. Novikov; M. Wiberg is a Medicine article available to read on EtoBox.

What is Neuronal Survival Using a Resorbable Synthetic Conduit as an Alternative to Primary Nerve Repair about?

Clinically optimal situations for primary nerve repair are rarely observed. Crushed nerve ends result in either suboptimal repair or a need for nerve grafting. Functional results after nerve surgery are relatively poor, including major sensory deficits, which may be due to the death of primary sensory neurons that follows the nerve injury. The aim of this study was to determine if using polyhydroxybutyrate (PHB), a resorbable nerve conduit, could be an alternative to primary nerve repair in reducing loss of neurons. The superficial radial nerves in 20 cats were sectioned bilaterally and primarily repaired microsurgically by the use of two different strate-gies; either wrapping the nerve ends in sheets of PHB or epineurally suturing of the nerve. After 6 or 12 months, the surviving neurons within the dorsal root ganglia [C5-T1] were counted. No statistically significant differences were found between the two methods. This may imply a future possibility of using PHB as a synthetic nerve graft in situations where suboptimal primary repair or nerve grafts are the alternatives.

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Author

C. Ljungberg; G. Johansson-Ruden; K. Junemo Bostrm; L. Novikov; M. Wiberg

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0738-1085)

Published

1999

Language

EN

Field

Medicine (Health Sciences)