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Hemostatic Properties of Glucosamine-based Materials by Thomas H. Fischer; Arthur P. Bode; Marina Demcheva; John N. Vournakis is a Engineering article available to read on EtoBox.

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## Abstract Glucosamine‐ and __N__‐acetyl glucosamine‐containing polymers are being used in an increasing number of biomedical applications, including in products for surface (topical) hemostasis. The studies presented here investigate the relationship between the structure (conformation) and function (activation of hemostasis) of glucosamine‐based materials. Several polymer systems were studied, including fibers isolated from a microalgal source containing poly‐__N__‐acetyl glucosamine polymers that are organized in a parallel, hydrogen‐bonded tertiary structure and can be chemically modified to an antiparallel orientation; and gel formulation derivatives of the microalgal fibers consisting of partially deacetylated (F2 gel) and fully deacetylated (F3 gel) polymers. Comparison of the properties of the poly‐__N__‐acetyl glucosamine fiber‐derived materials with chitin, chitosan, and commercial chitosan‐based products are presented. Several studies were performed with the glucosamine‐based materials, including (1) an analysis of the ability of materials to activate platelets and turnover of the intrinsic coagulation cascade, (2) an examination of the viscoelastic properties of mixtur

Who reads Hemostatic Properties of Glucosamine-based Materials?

Author

Thomas H. Fischer; Arthur P. Bode; Marina Demcheva; John N. Vournakis

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1549-3296)

Published

2006

Language

EN

Field

Engineering (Physical Sciences)