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Hypothesis of a CD137/Eomes activating axis for effector T cells in HPV oropharyngeal cancers by Robin Baudouin; Eric Tartour; Cécile Badoual; Stéphane Hans is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Hypothesis of a CD137/Eomes activating axis for effector T cells in HPV oropharyngeal cancers about?

Chronic Human Papilloma Virus (HPV) infection is supplanting alcohol and tobacco intoxications as the leading cause of oropharyngeal cancer in developed countries. HPV-related squamous cell carcinomas of the oropharynx (HPV + OSC) present better survival and respond better to radiotherapy and chemotherapy. Regulatory T cells (T~REG~) are mainly described as immunosuppressive and protumoral in most solid cancers. However, T~REG~ are paradoxically associated with a better prognosis in HPV + OSCs. The transcription factor FoxP3 is the basis for the identification of T~REG~. Among CD4 + FoxP3 + T cells, some have effector functions. A medical hypothesis is formulated here: the existence of a CD137 (4.1BB)-Eomesodermin (Eomes) activated pathway downstream of TCR-specific activation in a subpopulation of CD4 + FoxP3 + T cells may explain this effector function. Evidence suggest that this axis may exist either in CD4 + FoxP3 + T cells or CD8 + T cells. This pathway could lead T cells to strong antitumor cytotoxic activity in a tumor-specific manner. Furthermore, CD137 is one of the most expected targets for the development of agonist immunotherapies. The identification of CD137 + Eomes +

Who reads Hypothesis of a CD137/Eomes activating axis for effector T cells in HPV oropharyngeal cancers?

Author

Robin Baudouin; Eric Tartour; Cécile Badoual; Stéphane Hans

Publisher

BioMed Central

Published

2024

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)