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Bone Regeneration on Computer-designed Nano-fibrous Scaffolds by Victor J. Chen; Laura A. Smith; Peter X. Ma is a Engineering article available to read on EtoBox.

What is Bone Regeneration on Computer-designed Nano-fibrous Scaffolds about?

The ability to control architectural features in tissue engineering scaffolds is critical to the success of neo-tissue regeneration. In this work, reverse solid freeform fabrication and thermal phase separation of poly(L-lactic acid) (PLLA) solutions were used to create three-dimensional nano-fibrous (NF) scaffolds with complex geometries on the macro- and micro-scales. This approach allows for the fabrication of NF matrices while having precise control of internal pore size and structure, as well as external scaffold shape including architectures generated from computed-tomography scans and histological sections. In vitro cell cultivation experiments with MC3T3-E1 pre-osteoblasts were performed on NF scaffolds and on similarly designed solid-walled (SW) scaffolds that did not have nano-fibers. Proliferation studies showed significantly more cells on NF scaffolds after 7 d. In differentiation studies, the NF scaffolds displayed more uniform matrix and mineral production throughout. Real-time PCR also showed significantly higher expression of osteocalcin and bone sialoprotein mRNAs after 2 and 6 weeks in the NF scaffolds. Expression of type I collagen mRNA was lower in NF scaffolds

Who reads Bone Regeneration on Computer-designed Nano-fibrous Scaffolds?

Author

Victor J. Chen; Laura A. Smith; Peter X. Ma

Publisher

Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0142-9612)

Published

2006

Language

EN

Field

Engineering (Physical Sciences)