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Preclinical and Clinical Studies of Immunotherapy for the Treatment of Cholangiocarcinoma by Xinjun Lu; Benjamin L. Green; Changqing Xie; Chao Liu; Xin Chen is a Medicine article available to read on EtoBox.
What is Preclinical and Clinical Studies of Immunotherapy for the Treatment of Cholangiocarcinoma about?
## Summary Cholangiocarcinoma (CCA) is a rare primary liver cancer associated with high mortality and few systemic treatment options. The behaviour of the immune system has come into focus as a potential treatment modality for many cancer types, but immunotherapy has yet to dramatically alter the treatment paradigm for CCA as it has for other diseases. Herein, we review recent studies describing the relevance of the tumour immune microenvironment (TIME) in CCA. Various non-parenchymal cell types are critically important in controlling CCA progression, prognosis, and response to systemic therapy. Knowledge of the behaviour of these leukocytes could help generate hypotheses to guide the development of potential immune-directed therapies. Recently, an immunotherapy-containing combination was approved for the treatment of advanced-stage CCA. However, despite level 1 evidence demonstrating the improved efficacy of this therapy, survival remained suboptimal. In the current manuscript, we provide a comprehensive review of the TIME in CCA, preclinical studies of immunotherapies against CCA, as well as ongoing clinical trials applying immunotherapies for the treatment of CCA. Particular emp
Who reads Preclinical and Clinical Studies of Immunotherapy for the Treatment of Cholangiocarcinoma?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Xinjun Lu; Benjamin L. Green; Changqing Xie; Chao Liu; Xin Chen
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Medicine (Health Sciences)