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Lymphomas associated with Epstein-Barr virus infection in 2020: Results from a large, unselected case series in France by Marie Donzel; Maxime Bonjour; Jean-Damien Combes; Florence Broussais; Pierre Sesques; Alexandra Traverse-Glehen; Catherine de Martel is a Medicine article available to read on EtoBox.
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## Background: Despite mounting evidence for a causal role in an increasing number of lymphoma subtypes, very few studies have systematically tested the entire spectrum of hodgkin and non-hodgkin lymphomas for the presence of epstein-barr virus (ebv). here, we describe the prevalence of ebv in a large, unselected series of patients diagnosed with any type of lymphoma during 2020, in the pathology department of a single university hospital in france. ## Methods: A total of 756 lymphoma cases (89% new diagnoses and 11% relapses), were registered in the department between jan 1 and sept 30, 2020 and 616 were successfully tested for ebv presence in tumour cells by ebv-encoding rna in-situ hybridisation, using double-blinded assessment and a scoring system designed in accordance with the current state of knowledge in the literature. ## Findings: A strong association with ebv was described in 27/87 (31%) classic hodgkin lymphomas, 12/223 (5%) diffuse large b-cell lymphomas, and 18/71 (25%) nk and t-cell lymphomas: 4 extranodal nk/t-cell lymphomas, nasal type, 14 angioimmunoblastic t-cell lymphomas (48%). in hodgkin and nk and t-cell lymphomas, there was a statistically significant associ
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- Author
- Marie Donzel; Maxime Bonjour; Jean-Damien Combes; Florence Broussais; Pierre Sesques; Alexandra Traverse-Glehen; Catherine de Martel
- Publisher
- Elsevier BV
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)