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Altered sex hormone concentrations and gonadal mRNA expression levels of activin signaling factors in hatchling alligators from a contaminated Florida lake by Brandon C. Moore; Satomi Kohno; Robert W. Cook; Ashley L. Alvers; Heather J. Hamlin; Teresa K. Woodruff; Louis J. Guillette is a Environmental Science article available to read on EtoBox.
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## Abstract Activins and estrogens participate in regulating the breakdown of ovarian germ cell nests and follicle assembly in mammals. In 1994, our group reported elevated frequencies of abnormal, multioocytic ovarian follicles in 6 month old, environmental contaminant‐exposed female alligators after gonadotropin challenge. Here, we investigated if maternal contribution of endocrine disrupting contaminants to the egg subsequently alters estrogen/inhibin/activin signaling in hatchling female offspring, putatively predisposing an increased frequency of multioocytic follicle formation. We quantified basal and exogenous gonadotropin‐stimulated concentrations of circulating plasma steroid hormones and ovarian activin signaling factor mRNA abundance in hatchling alligators from the same contaminated (Lake Apopka) and reference (Lake Woodruff) Florida lakes, as examined in 1994. Basal circulating plasma estradiol and testosterone concentrations were greater in alligators from the contaminated environment, whereas activin/inhibin βA subunit and follistatin mRNA abundances were lower than values measured in ovaries from reference lake animals. Challenged, contaminant‐exposed animals showed
Who reads Altered sex hormone concentrations and gonadal mRNA expression levels of activin signaling factors in hatchling alligators from a contaminated Florida lake?
It is typically read by researchers, students, and practitioners in Environmental Science.
- Author
- Brandon C. Moore; Satomi Kohno; Robert W. Cook; Ashley L. Alvers; Heather J. Hamlin; Teresa K. Woodruff; Louis J. Guillette
- Publisher
- Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1932-5223)
- Published
- 2010
- Language
- EN
- Field
- Environmental Science (Life Sciences)