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Structural basis for mouse receptor recognition by SARS-CoV-2 omicron variant by Wei Zhang; Ke Shi; Qibin Geng; Gang Ye; Hideki Aihara; Fang Li is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Structural basis for mouse receptor recognition by SARS-CoV-2 omicron variant about?

## Significance Tracking the animal reservoir of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and its variants is important for understanding the current COVID-19 pandemic and preventing future pandemics. Speculations about the source of the omicron variant are abundant, yet experimental evidence has been scarce. Here, we provide the structural information on how omicron recognizes its mouse receptor. Our study demonstrates that the omicron mutations in the receptor-binding region are structurally adapted to mouse angiotensin-converting enzyme 2 (ACE2), informing an understanding of the origin of the omicron variant and the evolution of SARS-CoV-2. It may facilitate epidemiological surveillance of SARS-CoV-2 in animals to prevent future coronavirus pandemics.

Who reads Structural basis for mouse receptor recognition by SARS-CoV-2 omicron variant?

Author

Wei Zhang; Ke Shi; Qibin Geng; Gang Ye; Hideki Aihara; Fang Li

Publisher

Proceedings of the National Academy of Sciences

Published

2022

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)