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Doxycycline Prevents and Reverses Schizophrenic-like Behaviors Induced by Ketamine in Mice via Modulation of Oxidative, Nitrergic and Cholinergic Pathways by Benneth Ben-Azu; Itivere Adrian Omogbiya; Adegbuyi Oladele Aderibigbe; Solomon Umukoro; Abayomi Mayowa Ajayi; Ezekiel O. Iwalewa is a Neuroscience article available to read on EtoBox.
What is Doxycycline Prevents and Reverses Schizophrenic-like Behaviors Induced by Ketamine in Mice via Modulation of Oxidative, Nitrergic and Cholinergic Pathways about?
The involvement of oxidative, nitrergic, cholinergic and inflammatory alterations have been reported to contribute to the pathophysiology of schizophrenia, a debilitating neuropsychiatric disorder. Our previous studies have shown that doxycycline (DOX), a notable member of tetracyclines with proven antioxidant and anti-inflammatory properties, attenuated psychotic-like behaviors induced by apomophine and ketamine (KET) in mice. This present study was designed to further evaluate in detail the ability of DOX and its combination with risperidone (RIS) to prevent and reverse KET-induced schizophrenic-like behaviors and the role of oxidative/nitrergic and cholinergic pathways in mice. In the prevention protocol, mice were treated orally with DOX (25, 50 or 100 mg/kg), RIS (0.5 mg/kg), DOX (50 mg/kg) in combination with RIS, or vehicle for 14 consecutive days. In addition, the animals received intraperitoneal injection of KET (20 mg/kg/day) from the 8th to the 14th day. In the reversal protocol, the animals received KET or vehicle for 14 days prior to DOX, RIS, DOX in-combination with RIS or vehicle treatments. Schizophrenic-like behaviors consisting of positive, negative and cognitive
Who reads Doxycycline Prevents and Reverses Schizophrenic-like Behaviors Induced by Ketamine in Mice via Modulation of Oxidative, Nitrergic and Cholinergic Pathways?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- Benneth Ben-Azu; Itivere Adrian Omogbiya; Adegbuyi Oladele Aderibigbe; Solomon Umukoro; Abayomi Mayowa Ajayi; Ezekiel O. Iwalewa
- Publisher
- Elsevier BV
- Published
- 2018
- Language
- EN
- Field
- Neuroscience (Life Sciences)