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Can I read Developmentally Regulated Alternate 3′ End Cleavage of Nascent Transcripts Controls Dynamic Changes in Protein Expression in an Adult Stem Cell Lineage on EtoBox?
Developmentally Regulated Alternate 3′ End Cleavage of Nascent Transcripts Controls Dynamic Changes in Protein Expression in an Adult Stem Cell Lineage by Cameron W. Berry; Gonzalo H. Olivares; Lorenzo Gallicchio; Gokul Ramaswami; Alvaro Glavic; Patricio Olguín; Jin Billy Li; Margaret T. Fuller is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Developmentally Regulated Alternate 3′ End Cleavage of Nascent Transcripts Controls Dynamic Changes in Protein Expression in an Adult Stem Cell Lineage about?
In this study, Berry et al. identified >500 __Drosophila__ genes that express mRNA isoforms with a long 3′ UTR in proliferating spermatogonia but a short 3′ UTR in differentiating spermatocytes due to APA. Overall, they show that the developmentally regulated choice of an alternative site at which to make the 3′ end cut that terminates nascent transcripts can profoundly affect the suite of proteins expressed as cells advance through sequential steps in a differentiation lineage.
Who reads Developmentally Regulated Alternate 3′ End Cleavage of Nascent Transcripts Controls Dynamic Changes in Protein Expression in an Adult Stem Cell Lineage?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Cameron W. Berry; Gonzalo H. Olivares; Lorenzo Gallicchio; Gokul Ramaswami; Alvaro Glavic; Patricio Olguín; Jin Billy Li; Margaret T. Fuller
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)