About this Engineering article

Nanostructural Characteristics, Mechanical Properties, and Osteoblast Response of Spark Plasma Sintered Hydroxyapatite by H. Li; K.A. Khor; V. Chow; P. Cheang is a Engineering article available to read on EtoBox.

## Abstract This study aimed to fabricate bulk nanostructured hydroxyapatite (HA) pellets with improved properties using spark plasma sintering (SPS) for orthopedic applications. Spray‐dried nanostructured HA (nSD‐HA) powders were consolidated using the rapid SPS processing. The SPS processed nSD‐HA was characterized using Raman spectroscopy and field emission scanning electron microscopy (FESEM). Mechanical properties of the consolidates were also evaluated through indentation approach. The nanostructures (∼80 nm in grain size) of the starting powders were successfully retained after the SPS processing operated at 950°C with <15 min holding time. The SPS consolidated nSD‐HA showed promising mechanical properties, ∼118 GPa for Young's modulus, and up to 2.22 MPa m^0.5^ for fracture toughness. SPS holding time showed minor influence on the phases of the pellets. Furthermore, the spheroidized nanostructured HA retained the HA structure after the SPS consolidation. Preliminary cytotoxicity and cell attachment studies were also carried out using a human osteoblast cell line hFOB 1.19. Enhanced cell attachment and proliferation on the nanostructured pellets were revealed. The presence o

Author

H. Li; K.A. Khor; V. Chow; P. Cheang

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1549-3296)

Published

2007

Language

EN

Field

Engineering (Physical Sciences)