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The effect of chronic emotional stress on the humoral immune response to Porphyromonas gingivalis in mice by Yael Houri‐Haddad; Oded Itzchaki; David Ben‐Nathan; Lior Shapira is a Dentistry article available to read on EtoBox.

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Previous studies have shown that psychological stress plays a significant role in the outcome of infectious diseases, but data related to the effect of stress on periodontal infection is limited. The present study was designed to test the impact of emotional stress on the humoral immune response to the periodontal pathogen __Porphyromonas gingivalis__ in a mouse model of local inflammation. Chambers constructed from titanium wire were implanted in the subcutaneous dorsolumbar region of mice. All mice were immunized with __P. gingivalis__ followed by an intrachamber challenge with the bacteria. One group of mice was used as control, while the other two experienced experimental stress conditions (isolation/restraint stress). Stress‐1 group was stressed during the immunization period, while Stress‐2 group was stressed during the local challenge period. Chamber exudates and serum were collected and analyzed for levels of anti‐__P. gingivalis__ antibodies (IgG, IgG1 and IgG2a). The levels of serum antibodies to __P. gingivalis__ were not different between the three tested groups, excluding increased levels of IgG2a in Stress‐1 group at baseline. The levels of antibodies in the chamber e

Who reads The effect of chronic emotional stress on the humoral immune response to Porphyromonas gingivalis in mice?

Author

Yael Houri‐Haddad; Oded Itzchaki; David Ben‐Nathan; Lior Shapira

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0022-3484)

Published

2003

Language

EN

Field

Dentistry (Health Sciences)