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NMDA receptor antagonists failed in clinical trials for stroke and traumatic brain injury despite showing neuroprotective effects in animal models. The authors hypothesize that this is because glutamate plays a normal physiological role in promoting neuronal survival after the initial injury period through NMDA receptor-mediated synaptic transmission. Blocking NMDA receptors may therefore hinder neuronal survival in humans. While drug properties and trial design have been cited as reasons for failure, the u

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