Can I read A Parabrachial-to-Amygdala Circuit That Determines Hemispheric Lateralization of Somatosensory Processing on EtoBox?

A Parabrachial-to-Amygdala Circuit That Determines Hemispheric Lateralization of Somatosensory Processing by Heather N. Allen; Sarah Chaudhry; Veronica M. Hong; Lakeisha A. Lewter; Ghanshyam P. Sinha; Yarimar Carrasquillo; Bradley K. Taylor; Benedict J. Kolber is a Neuroscience article available to read on EtoBox.

What is A Parabrachial-to-Amygdala Circuit That Determines Hemispheric Lateralization of Somatosensory Processing about?

Background The central amygdala (CeA) is a bilateral hub of pain and emotional processing with well-established functional lateralization. We reported that optogenetic manipulation of neural activity in the left and right CeA has opposing effects on bladder pain. Methods To determine the influence of calcitonin gene-related peptide (CGRP) signaling from the parabrachial nucleus on this diametrically opposed lateralization, we administered CGRP and evaluated the activity of CeA neurons in acute brain slices as well as the behavioral signs of bladder pain in the mouse. Results We found that CGRP increased firing in both the right and left CeA neurons. Furthermore, we found that CGRP administration in the right CeA increased behavioral signs of bladder pain and decreased bladder pain–like behavior when administered in the left CeA. Conclusions These studies reveal a parabrachial-to-amygdala circuit driven by opposing actions of CGRP that determines hemispheric lateralization of visceral pain.

Who reads A Parabrachial-to-Amygdala Circuit That Determines Hemispheric Lateralization of Somatosensory Processing?

Author

Heather N. Allen; Sarah Chaudhry; Veronica M. Hong; Lakeisha A. Lewter; Ghanshyam P. Sinha; Yarimar Carrasquillo; Bradley K. Taylor; Benedict J. Kolber

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Neuroscience (Life Sciences)