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Can I read Genome‐wide approaches in the study of microRNA biology on EtoBox?
Genome‐wide approaches in the study of microRNA biology by Melissa L. Wilbert; Gene W. Yeo is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Genome‐wide approaches in the study of microRNA biology about?
## Abstract MicroRNAs (miRNAs), a class of ∼21–23 nucleotide long non‐coding RNAs (ncRNAs), have critical roles in diverse biological processes that encompass development, proliferation, apoptosis, stress response, and fat metabolism. miRNAs recognize their target mRNA transcripts by partial sequence complementarity and collectively have been estimated to regulate the majority of human genes. Consequently, misregulation of miRNAs or disruption of their target sites in genes has been implicated in a variety of human diseases ranging from cancer metastasis to neurological disorders. With the development and availability of genomic technologies and computational approaches, the field of miRNA biology has advanced tremendously over the last decade. Here we review the genome‐wide approaches that have allowed for the discovery of new miRNAs, the characterization of their targets, and a systems‐level view of their impact. __WIREs Syst Biol Med__ 2011 3 491–512 DOI: 10.1002/wsbm.128 This article is categorized under: Laboratory Methods and Technologies > Genetic/Genomic Methods
Who reads Genome‐wide approaches in the study of microRNA biology?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- Melissa L. Wilbert; Gene W. Yeo
- Publisher
- Wiley (John Wiley & Sons); John Wiley and Sons Inc.; Wiley (ISSN 1939-5094)
- Published
- 2010
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)