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This document compares the structurally related kynurenine pathway metabolites anthranilic acid (ANA) and 3-hydroxyanthranilic acid (3-HANA). It finds that both metabolites are redox active and can act as antioxidants. However, 3-HANA is much more unstable than ANA when attacked by hydroxyl radicals in oxidative stress scenarios. The high redox reactivity of 3-HANA in the presence of iron(II) helps explain why patients with neurological diseases often have decreased levels of this metabolite. Mass spectrome

Author

nila karina

Language

EN