Can I read Shrink Polymer Based Electrochemical Sensor for Point-of-care Detection of Prostate-specific Antigen on EtoBox?

Shrink Polymer Based Electrochemical Sensor for Point-of-care Detection of Prostate-specific Antigen by Wenzheng He; Liying Liu; Zeyuan Cao; Yang Lin; Yuxin Tian; Qifu Zhang; Changdong Zhou; Xiongying Ye; Tianhong Cui is a Engineering article available to read on EtoBox.

What is Shrink Polymer Based Electrochemical Sensor for Point-of-care Detection of Prostate-specific Antigen about?

There is a growing but unmet need for point-of-care detection of prostate-specific antigen (PSA) in body fluid which may facilitate early diagnosis and therapy of prostate cancer in a cost-effective and user-friendly way. Low sensitivity and narrow detection range limits applications of point-of-care testing in practice. Here, an immunosensor is first presented based on shrink polymer and integrated into a miniaturized electrochemical platform for detecting PSA in clinical samples. The sensing electrode was prepared by sputtering a gold film on shrink polymer, followed by heating to shrink the electrode to a small size with wrinkles from nano-scale to micro-scale. These wrinkles can be directly regulated by the thickness of the gold film with high specific areas for enhancement of antigen-antibody binding (3.9 times). A distinct difference between electrochemical active surface area (EASA) and response to PSA of shrink electrodes was observed and discussed. The electrode was treated with air plasma and modified with self-assembled graphene to further enhance the sensor's sensitivity (10.4 times). The shrink sensor with gold 200 nm thick integrated into the portable system was valid

Who reads Shrink Polymer Based Electrochemical Sensor for Point-of-care Detection of Prostate-specific Antigen?

Author

Wenzheng He; Liying Liu; Zeyuan Cao; Yang Lin; Yuxin Tian; Qifu Zhang; Changdong Zhou; Xiongying Ye; Tianhong Cui

Publisher

Elsevier BV

Published

2023

Language

EN

Field

Engineering (Physical Sciences)