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Sorafenib as first-line therapy in patients with advanced Child-Pugh B hepatocellular carcinoma—a meta-analysis by Mairéad Geraldine McNamara; Astrid E. Slagter; Christina Nuttall; Melissa Frizziero; Rille Pihlak; Angela Lamarca; Noor Tariq; Juan W. Valle; Richard A. Hubner; Jennifer J. Knox; Eitan Amir is a Medicine article available to read on EtoBox.

What is Sorafenib as first-line therapy in patients with advanced Child-Pugh B hepatocellular carcinoma—a meta-analysis about?

## Background: Sorafenib has demonstrated survival benefit in first-line treatment of advanced hepatocellular carcinoma (hcc); utility of sorafenib in patients with advanced hcc and child-pugh b (cp-b) liver function remains a subject of debate. ## Methods: A systematic review identified studies using first-line sorafenib in patients with advanced hcc and cp-a/b liver function. meta-regression analysis comprising linear regression was conducted to explore the association between the baseline factors and overall survival (os). differences between efficacy/safety and tolerability parameters were explored using meta-analysis. ## Results: Thirty studies (12 asian) comprising 8678 patients (august 2002 - september 2012) were included (four randomised controlled trials, 26 cohort studies). median age was 61 years and 83% were men. hepatitis b/c status was positive in 35%/22%, respectively. the cp status was available for 8577 patients (99%); cp-a, 79% and cp-b, 19%. median os on sorafenib for entire cohort was 7.2 months; 8.8 months in cp-a and 4.6 months in cp-b. multivariable meta-regression analysis showed significant negative association between os and proportion of patients with the

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Author

Mairéad Geraldine McNamara; Astrid E. Slagter; Christina Nuttall; Melissa Frizziero; Rille Pihlak; Angela Lamarca; Noor Tariq; Juan W. Valle; Richard A. Hubner; Jennifer J. Knox; Eitan Amir

Published

2018

Language

EN

Field

Medicine (Health Sciences)