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Functional Precision Oncology Using Patient-derived Assays: Bridging Genotype and Phenotype by Allard W. J. van Renterghem; Joris van de Haar; Emile E. Voest is a Medicine article available to read on EtoBox.

What is Functional Precision Oncology Using Patient-derived Assays: Bridging Genotype and Phenotype about?

Genomics-based precision medicine has revolutionized oncology but also has inherent limitations. Functional precision oncology is emerging as a complementary approach that aims to bridge the gap between genotype and phenotype by modelling individual tumours in vitro. These patient-derived ex vivo models largely preserve several tumour characteristics that are not captured by genomics approaches and enable the functional dissection of tumour vulnerabilities in a personalized manner. In this Review, we discuss several examples of personalized functional assays involving tumour organoids, spheroids and explants and their potential to predict treatment responses and drug-induced toxicities in individual patients. These developments have opened exciting new avenues for precision oncology, with the potential for successful clinical applications in contexts in which genomic data alone are not informative. To implement these assays into clinical practice, we outline four key barriers that need to be overcome: assay success rates, turnaround times, the need for standardized conditions and the definition of in vitro responders. Furthermore, we discuss novel technological advances such as mic

Who reads Functional Precision Oncology Using Patient-derived Assays: Bridging Genotype and Phenotype?

Author

Allard W. J. van Renterghem; Joris van de Haar; Emile E. Voest

Publisher

Springer Science and Business Media LLC

Published

2023

Language

EN

Field

Medicine (Health Sciences)