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Long‐term decrease of CD4^+^CD45RA^+^ T cells and impaired primary immune response after post‐traumatic splenectomy by Hermann M. Wolf; Martha M. Eibl; Erich Georgi; Aysen Samstag; Martin Spatz; Selman Uranüs; Rainer Passl is a Medicine article available to read on EtoBox.
What is Long‐term decrease of CD4^+^CD45RA^+^ T cells and impaired primary immune response after post‐traumatic splenectomy about?
Congenital or acquired absence of the spleen and functional hyposplenism are associated with abnormalities of host defence such as an increased susceptibility to infection with encapsulated bacteria. The effects of the lack of the spleen on cell‐mediated immunity are largely unknown. In the present study we have investigated peripheral blood lymphocyte subpopulations in healthy adults who had undergone splenectomy because of severe abdominal trauma > 4 years before the study. The results show a significant reduction in the percentage of CD4^+^ T cells due to a selective and long‐term decrease in the percentage of CD4^+^CD45RA^+^ lymphocytes, the CD4^+^ T‐cell subset mainly involved in primary immune responses to newly encountered antigens. Levels of the reciprocal CD45RO^+^CD4^+^ T‐cell subset were comparable between splenectomized and control individuals, as were lymphoproliferative responses and IFN‐gamma production to recall antigens. Decreased levels of CD4^+^CD45RA^+^ cells were accompanied by an impairment in primary immune responsiveness, as assessed by investigating T‐cell proliferation to stimulation with keyhole limpet haemocyanin and by measuring antibody responses follo
Who reads Long‐term decrease of CD4^+^CD45RA^+^ T cells and impaired primary immune response after post‐traumatic splenectomy?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Hermann M. Wolf; Martha M. Eibl; Erich Georgi; Aysen Samstag; Martin Spatz; Selman Uranüs; Rainer Passl
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0007-1048)
- Published
- 1999
- Language
- EN
- Field
- Medicine (Health Sciences)