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Virulence gene profiling of enterohemorrhagic (EHEC) and enteropathogenic (EPEC) Escherichia coli strains: a basis for molecular risk assessment of typical and atypical EPEC strains by Marie Bugarel; Annett Martin; Patrick Fach; Lothar Beutin is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Background Enterohaemorrhagic __E. coli__ (EHEC) can cause severe disease such as bloody diarrhoea and haemolytic uraemic syndrome in humans. Besides production of Shiga toxins, the presence of LEE (__eae__-gene) and non-LEE (__nle__) encoded effector genes harboured on O-islands OI-122, OI-71 and OI-57 is associated with EHEC virulence and their frequency in outbreaks. Genes encoded by the EHEC-plasmid are putative virulence markers of EHEC. EHEC-plasmids, LEE and non-LEE effector genes have also been detected in some strains of enteropathogenic __E. coli__ (EPEC). The objective of this study was to analyze the relationship between EHEC and EPEC for virulence genes encoded by genomic O-islands and by the EHEC-plasmids. ## Results Nle genes __ent/espL2__, __nleB__ and __nleE__ (OI-122), __nleA__, __nleF__ and __nleH1-2__ (OI-71), __nleG5-2__ and __nleG6-2__ (OI-57), __espK__ (CP-933N) and the EHEC-plasmid encoded genes __ehxA__, __espP__, __etpD__ and __katP__ were searched in 73 typical and in 235 atypical enteropathogenic __E. coli__ (EPEC) strains. Typical and atypical EPEC each fall into two clusters. Cluster 1 typical (n = 46) and atypical (n = 129) EPEC strains were charac

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Author

Marie Bugarel; Annett Martin; Patrick Fach; Lothar Beutin

Publisher

BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, 2001-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2180)

Published

2011

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)