Can I read Inhibition Studies of Mycobacterium tuberculosis Salicylate Synthase (MbtI) on EtoBox?

Inhibition Studies of Mycobacterium tuberculosis Salicylate Synthase (MbtI) by Alexandra Manos‐Turvey; Esther M. M. Bulloch; Peter J. Rutledge; Edward N. Baker; J. Shaun Lott; Richard J. Payne is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Inhibition Studies of Mycobacterium tuberculosis Salicylate Synthase (MbtI) about?

## Abstract Mycobacterium tuberculosis __salicylate synthase (MbtI), a member of the chorismate‐utilizing enzyme family, catalyses the first committed step in the biosynthesis of the siderophore mycobactin T. This complex secondary metabolite is essential for both virulence and survival of__ M. tuberculosis__, the etiological agent of tuberculosis (TB). It is therefore anticipated that inhibitors of this enzyme may serve as TB therapies with a novel mode of action. Herein we describe the first inhibition study of__ M. tuberculosis __MbtI using a library of functionalized benzoate‐based inhibitors designed to mimic the substrate (chorismate) and intermediate (isochorismate) of the MbtI‐catalyzed reaction. The most potent inhibitors prepared were those designed to mimic the enzyme intermediate, isochorismate. These compounds, based on a 2,3‐dihydroxybenzoate scaffold, proved to be low‐micromolar inhibitors of MbtI. The most potent inhibitors in this series possessed hydrophobic enol ether side chains at C3 in place of the enol‐pyruvyl side chain found in chorismate and isochorismate.__

Who reads Inhibition Studies of Mycobacterium tuberculosis Salicylate Synthase (MbtI)?

Author

Alexandra Manos‐Turvey; Esther M. M. Bulloch; Peter J. Rutledge; Edward N. Baker; J. Shaun Lott; Richard J. Payne

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Wiley - V C H Verlag GmbbH & Co.; Wiley (ISSN 1860-7179)

Published

2010

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)