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Can I read Tumor-targeted delivery of a STING agonist improvescancer immunotherapy on EtoBox?
Tumor-targeted delivery of a STING agonist improvescancer immunotherapy by You-tong Wu; Yan Fang; Qi Wei; Heping Shi; Huiling Tan; Yafang Deng; Zhiqun Zeng; Jian Qiu; Chuo Chen; Lijun Sun; Zhijian J. Chen is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.
What is Tumor-targeted delivery of a STING agonist improvescancer immunotherapy about?
The cGAS-STING pathway is essential for immune defense against microbial pathogens and malignant cells; as such, STING is an attractive target for cancer immunotherapy. However, systemic administration of STING agonists poses safety issues while intratumoral injection is limited by tumor accessibility. Here, we generated antibody-drug conjugates (ADCs) by conjugating a STING agonist through a cleavable linker to antibodies targeting tumor cells. Systemic administration of these ADCs was well tolerated and exhibited potent antitumor efficacy in syngeneic mouse tumor models. The STING ADC further synergized with an anti-PD-L1 antibody to achieve superior antitumor efficacy. The STING ADC promoted multiple aspects of innate and adaptive antitumor immune responses, including activation of dendritic cells, T cells, natural killer cells and natural killer T cells, as well as promotion of M2 to M1 polarization of tumor-associated macrophages. These results provided the proof of concept for clinical development of the STING ADCs.
Who reads Tumor-targeted delivery of a STING agonist improvescancer immunotherapy?
It is typically read by researchers, students, and practitioners in Biochemistry, Genetics and Molecular Biology.
- Author
- You-tong Wu; Yan Fang; Qi Wei; Heping Shi; Huiling Tan; Yafang Deng; Zhiqun Zeng; Jian Qiu; Chuo Chen; Lijun Sun; Zhijian J. Chen
- Publisher
- Proceedings of the National Academy of Sciences
- Published
- 2022
- Language
- EN
- Field
- Biochemistry, Genetics and Molecular Biology (Life Sciences)