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Meconium Exposure Dependent Cell Death and Apoptosis in Human Alveolar Epithelial Cells by Mei-Jy Jeng; Wen-Jue Soong; Yu-Sheng Lee; Pei-Chen Tsao; Chia-Feng Yang; Shih-Yun Chiu; Ren-Bin Tang is a Medicine article available to read on EtoBox.

What is Meconium Exposure Dependent Cell Death and Apoptosis in Human Alveolar Epithelial Cells about?

## Abstract Alveolar epithelial cells of neonates are directly exposed to aspirated meconium during meconium aspiration syndrome (MAS). This study was designed to investigate the influence of quantity and time of meconium exposure on the cell viability and caspase activity in type II human alveolar epithelial cells. Human alveolar epithelial cells were incubated with human meconium suspension at different concentrations and for different times. Cell viability and DNA fragmentation were investigated together with caspases activity and the amount of Bcl‐2 protein present. We found that cell viability was significantly lower in cells exposed to a higher concentration of meconium. This was also true for cells exposed to meconium for longer. Significantly higher DNA fragmentation, an approximately two‐ to fivefold increase, was observed in cells that had been exposed to higher (5% and 10%) concentration of meconium compared to those treated with lower (0.1% and 1%) concentrations (__P__ < 0.05). The activity of most apoptotic initiators (caspase 2, 8, 9, 10) and effectors (caspase 3, 6) were found to be significantly higher in cells subject to greater meconium exposure compared to cells

Who reads Meconium Exposure Dependent Cell Death and Apoptosis in Human Alveolar Epithelial Cells?

Author

Mei-Jy Jeng; Wen-Jue Soong; Yu-Sheng Lee; Pei-Chen Tsao; Chia-Feng Yang; Shih-Yun Chiu; Ren-Bin Tang

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 8755-6863)

Published

2010

Language

EN

Field

Medicine (Health Sciences)