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Can I read On the Absolute Stereochemistry of (−)-4-Alkylnonan-2-ones on EtoBox?
On the Absolute Stereochemistry of (−)-4-Alkylnonan-2-ones by Victor Garcia-Ruiz; Simon Woodward is a Chemistry article available to read on EtoBox.
What is On the Absolute Stereochemistry of (−)-4-Alkylnonan-2-ones about?
The alcohols (S)-C 5 H 11 n CH(R)CH 2 OH (R=Me, Et) have been prepared by Evans' alkylation chemistry (>98% e.e.). For R=Me [h] D =-15.5 (c 0.31, MeOH); for R=Et [h] D =+6.8 (c 0.31, MeOH). Equivalent alcohols are obtained by Baeyer-Villiger oxidative cleavage of (S)-(-)-C 5 H 11 n CH(R)CH 2 COMe (R=Me, 85% e.e.; R=Et, 62% e.e.) derived from catalytic asymmetric conjugate addition. Thus, AlMe 3 or ZnEt 2 addition to the Si face of the enone generates a (-) antipode with a 4S stereocentre.
Who reads On the Absolute Stereochemistry of (−)-4-Alkylnonan-2-ones?
It is typically read by researchers, students, and practitioners in Chemistry.
- Author
- Victor Garcia-Ruiz; Simon Woodward
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0957-4166)
- Published
- 2002
- Language
- EN
- Field
- Chemistry (Physical Sciences)