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Paracrine Functions of the Coronary Vascular Endothelium by Ingrid Fleming; Johann Bauersachs; Rudi Busse is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is Paracrine Functions of the Coronary Vascular Endothelium about?

Coronary vascular endothelial cells control vascular tone by modulating the local concentration of circulating vasoactive substances (e.g. adenine nucleotides, biogenic amines and bradykinin) and by synthesising and releasing the vasoactive autacoids nitric oxide (NO) and prostacyclin (PGI2). The fluid shear stress exerted by the streaming blood is the physiologically most important stimulus for a continuous endothelial NO production, which counteracts neuro- and myogenic constriction. This shear stress-dependent NO release represents a highly effective local system for maintaining adequate blood flow to the myocardial tissue. At the transcriptional level endothelium-derived NO modulates the regulation of a number of genes (e.g. monocyte chemoattractant protein-1, P-selectin and vascular cell adhesion molecule-1) most probably by direct and/or indirect interaction with transcription factors. In addition to NO and PGI2, the coronary vascular endothelium is also able to release a factor which causes hyperpolarisation of the underlying smooth muscle. This so-called endothelium-derived hyperpolarising factor (EDHF) displays the characteristics of a cytochrome P450-derived arachidonic a

Who reads Paracrine Functions of the Coronary Vascular Endothelium?

Author

Ingrid Fleming; Johann Bauersachs; Rudi Busse

Publisher

Springer; Springer-Verlag; Kluwer Academic/Plenum Publishers; Springer Science and Business Media LLC (ISSN 0300-8177)

Published

1996

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)