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Biomaterial-based in vitro 3D modeling of glioblastoma multiforme by Tanvir Ahmed is a Medicine article available to read on EtoBox.

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Adult-onset brain cancers, such as glioblastomas, are particularly lethal. People with glioblastoma multiforme (GBM) do not anticipate living for more than 15 months if there is no cure. The results of conventional treatments over the past 20 years have been underwhelming. Tumor aggressiveness, location, and lack of systemic therapies that can penetrate the blood–brain barrier are all contributing factors. For GBM treatments that appear promising in preclinical studies, there is a considerable rate of failure in phase I and II clinical trials. Unfortunately, access becomes impossible due to the intricate architecture of tumors. __In vitro__, bioengineered cancer models are currently being used by researchers to study disease development, test novel therapies, and advance specialized medications. Many different techniques for creating __in vitro__ systems have arisen over the past few decades due to developments in cellular and tissue engineering. Later-stage research may yield better results if __in vitro__ models that resemble brain tissue and the blood–brain barrier are used. With the use of 3D preclinical models made available by biomaterials, researchers have discovered that it

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Author

Tanvir Ahmed

Publisher

Elsevier

Published

2023

Language

EN

Field

Medicine (Health Sciences)