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Resveratrol Ameliorates Contrast Induced Nephropathy Through the Activation of SIRT1-PGC-1α-Foxo1 Signaling in Mice by Yu Ah Hong; So Yeon Bae; Shin Young Ahn; Jieun Kim; Young Joo Kwon; Woon Yong Jung; Gang Jee Ko is a scholarly article available to read on EtoBox.

**__Background/Aims:__** SIRT1 activation promotes the resistance of renal tubular cells to oxidative stress, and resveratrol is known as a SIRT1 activator. **__Methods:__** Resveratrol was injected intraperitoneally with iohexol for 24 hours. NRK-52E cells were pretreated with resveratrol for 24 hours and then exposed to iohexol for 3 hours. Renal function was measured by serum creatinine and cell survival was assessed by MTT assay. We investigated whether resveratrol attenuates oxidative stress and apoptosis in contrast-induced nephropathy (CIN). **__Results:__** Serum creatinine and tubular injury increased significantly after iohexol treatment, and resveratrol co-treatment attenuated the renal injury. Cell survival decreased after iohexol exposure and resveratrol reduced cell death induced by iohexol. Resveratrol was accompanied with the activation of SIRT1 and PGC-1α and dephosphorylation of FoxO1 in mice with CIN. SIRT1 and PGC-1α expression were decreased by iohexol, and increased significantly in resveratrol-pretreated cells. These processes resulted in reduction of oxidative stress and apoptosis both __in vivo__ and __in vitro__ experiments. Resveratrol decreased inflammat

Author

Yu Ah Hong; So Yeon Bae; Shin Young Ahn; Jieun Kim; Young Joo Kwon; Woon Yong Jung; Gang Jee Ko

Publisher

S. Karger AG

Published

2017

Language

EN