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Metabolic differences between primary and recurrent human brain tumors: a ^1^H NMR spectroscopic investigation by Fritz‐Georg Lehnhardt; Christian Bock; Gabriele Röhn; Ralf‐Ingo Ernestus; Mathias Hoehn is a Medicine article available to read on EtoBox.
What is Metabolic differences between primary and recurrent human brain tumors: a ^1^H NMR spectroscopic investigation about?
## Abstract High‐resolution proton magnetic resonance spectroscopy was performed on tissue specimens from 33 patients with astrocytic tumors (22 astrocytomas, 11 glioblastomas) and 13 patients with meningiomas. For all patients, samples of primary tumors and their first recurrences were examined. Increased anaplasia, with respect to malignant transformation, resulting in a higher malignancy grade, was present in 11 recurrences of 22 astrocytoma patients. Spectroscopic features of tumor types, as determined on samples of the primary occurrences, were in good agreement with previous studies. Compared with the respective primary astrocytomas, characteristic features of glioblastomas were significantly increased concentrations of alanine (Ala) (__p__ = 0.005), increased metabolite ratios of glycine (Gly)/total creatine (tCr) (__p__ = 0.0001) and glutamate (Glu)/glutamine (Gln) (__p__ = 0.004). Meningiomas showed increased Ala (__p__ = 0.02) and metabolite ratios [Gly, total choline (tCho), Ala] over tCr (__p__ = 0.001) relative to astrocytomas, and __N__‐acetylaspartate and myo‐inositol were absent. Metabolic changes of an evolving tumor were observed in recurrent astrocytomas: owing t
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- Author
- Fritz‐Georg Lehnhardt; Christian Bock; Gabriele Röhn; Ralf‐Ingo Ernestus; Mathias Hoehn
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0952-3480)
- Published
- 2005
- Language
- EN
- Field
- Medicine (Health Sciences)