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Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned by Ryan Choi; Matthew A. Hulverson; Wenlin Huang; Rama S.R. Vidadala; Grant R. Whitman; Lynn K. Barrett; Deborah A. Schaefer; Dana P. Betzer; Michael W. Riggs; J. Stone Doggett; Andrew Hemphill; Luis Miguel Ortega-Mora; Molly C. McCloskey; Samuel L.M. Arnold; Robert C. Hackman; Kennan C. Marsh; James J. Lynch; Gail M. Freiberg; Bruce E. Leroy; Dale J. Kempf; Robert K.M. Choy; Eugenio L. de Hostos; Dustin J. Maly; Erkang Fan; Kayode K. Ojo; Wesley C. Van Voorhis is a Immunology and Microbiology article available to read on EtoBox.

What is Bumped Kinase Inhibitors as therapy for apicomplexan parasitic diseases: lessons learned about?

Bumped Kinase Inhibitors, targeting Calcium-dependent Protein Kinase 1 in apicomplexan parasites with a glycine gatekeeper, are promising new therapeutics for apicomplexan diseases. Here we will review advances, as well as challenges and lessons learned regarding efficacy, safety, and pharmacology that have shaped our selection of pre-clinical candidates.

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Author

Ryan Choi; Matthew A. Hulverson; Wenlin Huang; Rama S.R. Vidadala; Grant R. Whitman; Lynn K. Barrett; Deborah A. Schaefer; Dana P. Betzer; Michael W. Riggs; J. Stone Doggett; Andrew Hemphill; Luis Miguel Ortega-Mora; Molly C. McCloskey; Samuel L.M. Arnold; Robert C. Hackman; Kennan C. Marsh; James J. Lynch; Gail M. Freiberg; Bruce E. Leroy; Dale J. Kempf; Robert K.M. Choy; Eugenio L. de Hostos; Dustin J. Maly; Erkang Fan; Kayode K. Ojo; Wesley C. Van Voorhis

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0020-7519)

Published

2020

Language

EN

Field

Immunology and Microbiology (Life Sciences)