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Fecal Stream Diversion Changes Intestinal Environment, Modulates Mucosal Barrier, and Attenuates Inflammatory Cells in Crohn’s Disease by Yoshifumi Watanabe; Tsunekazu Mizushima; Ryu Okumura; Shiki Fujino; Takayuki Ogino; Norikatsu Miyoshi; Hidekazu Takahashi; Mamoru Uemura; Chu Matsuda; Hirofumi Yamamoto; Kiyoshi Takeda; Yuichiro Doki; Hidetoshi Eguchi is a Medicine article available to read on EtoBox.

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## Background: The intestinal environment plays important roles in mucosal barrier homeostasis and intestinal inflammation, as clarified in studies using experimental animals but not in humans. ## Aims: We investigated whether environmental changes in the fecal stream cause phenotypic changes in the human mucosal barrier. ## Methods: We obtained human ileal samples after fecal stream diversions in patients with rectal cancer or crohn's disease. we investigated the bacterial load and diversity in the human defunctioned ileum, defined as the anal side of the ileum relative to the ileostomy. we also examined the epithelium and lamina propria cell phenotypes in the defunctioned ileum. ## Results: After fecal stream diversion, bacterial loads decreased significantly in the defunctioned ileum. based on the chao1, shannon, and observed species indices, the diversity of mucosa-associated microbiota was lower in the defunctioned ileum than in the functional ileum. moreover, the healthy defunctioned ileum showed reductions in villous height, goblet cell numbers, and ki-67 cell numbers. additionally, interferon-γ, interleukin-17, and immunoglobulin a cell abundance in the lamina propria decre

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Author

Yoshifumi Watanabe; Tsunekazu Mizushima; Ryu Okumura; Shiki Fujino; Takayuki Ogino; Norikatsu Miyoshi; Hidekazu Takahashi; Mamoru Uemura; Chu Matsuda; Hirofumi Yamamoto; Kiyoshi Takeda; Yuichiro Doki; Hidetoshi Eguchi

Publisher

Springer Science and Business Media LLC

Published

2021

Language

EN

Field

Medicine (Health Sciences)