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Response to Endobronchial Valve Treatment: It's All About the Target Lobe by Jorine E. Hartman; Sharyn A. Roodenburg; Marlies van Dijk; T. David Koster; Karin Klooster; Dirk-Jan Slebos is a Medicine article available to read on EtoBox.

What is Response to Endobronchial Valve Treatment: It's All About the Target Lobe about?

## Background Bronchoscopic lung volume reduction using endobronchial valves (EBV) has been shown to be beneficial for severe emphysema patients. The most important predictor of treatment response is absence of collateral ventilation between the treatment target and ipsilateral lobe. However, there are still a substantial number of nonresponders and it would be useful to improve the pre-treatment identification of responders. Presumably, predictors of response will be multifactorial, and therefore our aim was to explore whether we can identify response groups using a cluster analysis. ## Methods At baseline and 1 year follow-up, pulmonary function, exercise capacity and quality of life were measured. A quantitative chest computed tomography scan analysis was performed at baseline and 2–6 months follow-up. The cluster analysis was performed using a hierarchical agglomerative method. ## Results In total, 428 patients (69% female, mean±sd age 61±8 years, forced expiratory volume in 1 s 27±8% predicted, residual volume 254±50% pred) were included in our analysis. Three clusters were generated: one nonresponder cluster and two responder clusters. Despite solid technical procedures, the

Who reads Response to Endobronchial Valve Treatment: It's All About the Target Lobe?

Author

Jorine E. Hartman; Sharyn A. Roodenburg; Marlies van Dijk; T. David Koster; Karin Klooster; Dirk-Jan Slebos

Publisher

European Respiratory Society (ERS)

Published

2023

Language

EN

Field

Medicine (Health Sciences)