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Can Early Diagnosis of Varices, Regular Praziquantel, and Reduction of Hepatitis Coinfection Reduce Mortality among Patients Attended for Periportal Fibrosis in Northwestern Tanzania? A Case-Control Study by Daniel W. Gunda; Elizabeth F. Mtui; Semvua B. Kilonzo; Paulina M. Manyiri; David C. Majinge; Humphrey D. Mazigo is a Medicine article available to read on EtoBox.

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## Background __Schistosoma mansoni__ is highly endemic in the Lake Zone part of Tanzania and most people are chronically infected. Periportal fibrosis (PPF) is the commonest complication of chronic __S. mansoni__ infection documented in up to 42% of studied participants in the community-based studies. These patients are at high risk of mortality since most of them are diagnosed late with bleeding varices. At Bugando, Schistosoma-related varices contributed to 70% of patients admitted due to vomiting blood with a two months' mortality of over 10%. Earlier studies had reported higher mortality of up to 29% among patients with PPF even with the best in-hospital care. Understanding factors that increased the risk of mortality is important clinically in devising ways that can improve the outcome of this subgroup of patients. ## Methods A retrospective analysis of patients with PPF from 2015 through 2018 was done. Their sociodemographic, clinical, laboratory, ultrasonographic, endoscopic, and survival status data were collected for analysis. STATA 13 was used for analysis, the prevalence of varices, active schistosomiasis, and hepatitis B coinfection was determined. Cumulative mortality

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Author

Daniel W. Gunda; Elizabeth F. Mtui; Semvua B. Kilonzo; Paulina M. Manyiri; David C. Majinge; Humphrey D. Mazigo

Publisher

Hindawi Limited; Hindawi Publishing Corporation; New York: Hindawi Pub. Corp., 2009-; London: Hindawi (ISSN 2090-0023)

Published

2020

Language

EN

Field

Medicine (Health Sciences)