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Development and Antibacterial Investigation of Linezolid-Loaded SPIONs and HPLC Method Development for Quantitative Analysis of Linezolid by Musarrat Husain Warsi; Sharmistha Mohapatra; Mohammed Asfer; Mohammad Yusuf; Abuzer Ali; Mohammad Akhlaquer Rahman; Amena Ali; Abdul Qadir; Gaurav K Jain is a scholarly article available to read on EtoBox.

What is Development and Antibacterial Investigation of Linezolid-Loaded SPIONs and HPLC Method Development for Quantitative Analysis of Linezolid about?

## Abstract ## Background Linezolid (LNZ) is extremely prone to resistance. The development of resistance to LNZ should be taken into consideration when selecting this drug as a therapeutic option. It is well established that reactive oxygen species (ROS) generated by iron oxide nanoparticles (MNPs) could kill the infecting bacteria. So, we hypothesized the synergistic antibacterial effect of iron oxide nanoparticles and LNZ. ## Objective To study the release and antibacterial effects of LNZ-loaded superparamagnetic iron oxide nanoparticles (SPIONs) on Staphylococcus aureus and Streptococcus pneumoniae. ## Method Ferrofluid containing SPIONs was synthesized via chemical co-precipitation method and stabilized by sodium lauryl sulphate (SLS). SPIONs were then loaded with LNZ and characterized for particle size, FT-IR, XRD, and entrapment efficiency. Further antibacterial activity of SPIONs and LNZ-loaded SPIONs was investigated. For the in vitro release findings, HPLC analytical method development and validation were performed. ## Results Isolation of LNZ was accomplished on a C-18 column with methanol–TBHS (tetra butyl ammonium hydrogen sulphate, 50:50, v/v). The eluate was monitore

Author

Musarrat Husain Warsi; Sharmistha Mohapatra; Mohammed Asfer; Mohammad Yusuf; Abuzer Ali; Mohammad Akhlaquer Rahman; Amena Ali; Abdul Qadir; Gaurav K Jain

Publisher

Oxford University Press (OUP)

Published

2023

Language

EN