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Can I read Preparation, Characterization, and in Vitro Drug Release Behavior of Biodegradable Chitosan-graft-poly(1, 4-Dioxan-2-one) Copolymer on EtoBox?
Preparation, Characterization, and in Vitro Drug Release Behavior of Biodegradable Chitosan-graft-poly(1, 4-Dioxan-2-one) Copolymer by Gui-Ying Liu; Yan-Li Zhai; Xiu-Li Wang; Wen-Tao Wang; Yan-Bo Pan; Xue-Ting Dong; Yu-Zhong Wang is a Materials Science article available to read on EtoBox.
What is Preparation, Characterization, and in Vitro Drug Release Behavior of Biodegradable Chitosan-graft-poly(1, 4-Dioxan-2-one) Copolymer about?
A novel copolymer of chitosan-g-poly(p-dioxanone) (CGP) was synthesized in bulk by ring-opening polymerization of p-dioxanone (PDO) initiated by the hydroxyl group or amino group of chitosan using SnOct 2 as catalyst. The chemical structure was determined by 1 H NMR. It was found that the feed ratio of chitosan to PDO had a great effect on the degree of polymerization (DP) and the substitution (DS) of PDO. The thermal stability and crystallization behavior of graft copolymer CGP were closely related to the values of DP and DS. When the resulting copolymer was used as Ibuprofen carrier, the release rate of Ibuprofen decreased compared with that of pure chitosan carrier. The drug release behavior was also influenced by the structure of graft copolymers.
Who reads Preparation, Characterization, and in Vitro Drug Release Behavior of Biodegradable Chitosan-graft-poly(1, 4-Dioxan-2-one) Copolymer?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Gui-Ying Liu; Yan-Li Zhai; Xiu-Li Wang; Wen-Tao Wang; Yan-Bo Pan; Xue-Ting Dong; Yu-Zhong Wang
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0144-8617)
- Published
- 2008
- Language
- EN
- Field
- Materials Science (Physical Sciences)