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This article presents a method for the efficient hydration of nitriles to form amides using a manganese(I) PCNHCP pincer complex, achieving high yields (up to 99%) at moderate temperatures (90 °C). The process is notable for its use of earth-abundant metals, mild conditions, and the ability to produce deuterated amides through H/D exchange. The study also explores the mechanistic pathway, highlighting the role of hydroxide ions generated from water activation in facilitating the reaction.

Author

guge19930310

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EN